The boys learn that Earth is actually a reality show for aliens and must save it from cancellation.
Timmy and Jimmy start a club for cripples, which draws attention from the Crips. Christopher Reeve comes to town to promote stem cell research.
The boys are caught in the middle of a town fight between people for the War in Iraq and people against it. Meanwhile, Cartman travels back in time to the late Colonial era by electrocuting himself.
Cartman's hand-puppet "Jennifer Lopez" garners major publicity, which angers the real Jennifer Lopez.
The boys' game of "police detectives" turns all too real when Sergeant Yates hires them to bust a drug deal.
The town is taken over by Native Americans who want to create a highway to their casino.
The men and boys of town become metrosexual. Meanwhile, Kyle, Mr. Slave, and Mr. Garrison try to stop the wave of metrosexuality when Kyle is treated like an outcast, and Mr. Garrison believes the metrosexual fad is cheapening the pride of real homosexuals.
Cartman, Token, and Butters form a Christian music band. Stan, Kyle, and Kenny protest against downloading music from the Internet after getting arrested.
The elderly have their driver's licenses taken away, against which the AARP retaliates.
Stan becomes a Goth after Wendy Testaburger breaks up with him. Meanwhile, Butters falls for Lexus, a waitress at a Hooters-esque restaurant called "Raisins".
Kyle and the boys fly to Canada during Christmas time to see the Canadian Prime Minister after Ike's biological parents take him back to Canada.